Clinical Significance of Endometrial Abnormalities in Patients with Breast Cancer after Oral Administration of Tamoxifen
- VernacularTitle:乳腺癌患者口服他莫昔芬后子宫内膜异常的临床意义
- Author:
Dongli TIAN
1
;
Fengxin LI
;
Lei DENG
;
Feiran SONG
;
Xiaoyan PANG
;
Yi ZHANG
Author Information
1. 中国医科大学附属第一医院妇科
- Keywords:
tamoxifen;
endometrial diseases;
abnormal uterine bleeding
- From:
Journal of China Medical University
2019;48(1):62-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical significance of endometrial abnormalities in patients with breast cancer after oral administration of tamoxifen, and to determine the risk factors for endometrial malignancy. Methods We collected data from 135 patients with breast cancer who underwent surgery for endometrial abnormalities after oral administration of tamoxifen at the Department of Gynecology from September 2011 to December 2017. According to the pathological results obtained, the patients were divided into groups A (benign endometrial lesion) and B (precancerous and malignant endometrial lesion). The relationships between endometrial malignancy and factors including age, menopausal status, body mass index, endometrial thickness, abnormal uterine bleeding, oral dose of tamoxifen, duration of oral medication, and complications (hypertension and diabetes) were compared between the groups. Results There were 124 patients in group A and 11 patients in group B. The difference in the incidence of abnormal uterine bleeding, which was a risk factor for endometrial malignancy, was significant different between the groups (P ＜ 0.05). Conclusion Physicians should pay close attention to abnormal uterine bleeding in patients taking tamoxifen after surgery for breast cancer. Hysteroscopy should be used to confirm the nature of lesions, and patients without symptoms should be followed up.
