Resting-state functional magnetic resonance imaging of supramarginal gyrus-cerebellum circuit in obsessive-compulsive disorder
10.3760/cma.j.issn.1674-6554.2019.02.006
- VernacularTitle:强迫症患者缘上回小脑环路静息态功能磁共振研究
- Author:
Qingjiang ZHAO
1
,
2
;
Haisan ZHANG
;
Bi WANG
;
Nan YAO
;
Yongfeng YANG
;
Luxian LYU
;
Hongxing ZHANG
;
Xiaoyue WANG
Author Information
1. 河南省精神病医院(新乡医学院第二附属医院)放射科 453002
2. 新乡市多模态脑影像重点实验室 453002
- Keywords:
Obsessive compulsive disorder;
Regional homogeneity;
Functional connection;
Supramarginal gyrus-cerebellum circuit
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(2):127-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective Regional homogeneity (ReHo) and functional connectivity (FC) were used to study obsessive-compulsive disorder(OCD),and to explore the mechanism of OCD in resting state.Method Resting-state functional magnetic resonance imaging (RS-fMRI) was performed in 55 patients with OCD (OCD group) and 50 normal controls (control group) matched by sex,age,nationality and education.The data and screening abnormal brain areas were analyzed and compared by DPARSFA2.3 and Rest software in OCD group.Whole brain FC analysis was performed with abnormal brain areas as seed points.Result Compared with the control group,ReHo in right thalamus (MNI:x=9,y=-24,z=6,t=4.3217) and left superior marginal gyrus (MNI:x =-45,y =-30,z =27,t =3.6320) increased and ReHo in right caudate nucleus (MNI:x=3,y=15,z=9,t=-3.1687) decreased in obsessive-compulsive disorder group,and the difference was statistically significant(P＜0.05).Using left superior marginal gyrus,fight thalamus and right caudate nucleus as seed voxels,the whole brain FC analysis showed that there were abnormal functional connections between bilateral cerebellar foot 1/2 area and left supramarginal gyrus,right thalamus and right caudate nucleus (P＜0.05) and the left supramarginal gyrus-bilateral cerebellum feet 1 area-right thalamic circuit and left supramarginal gyrus-bilateral cerebellum feet 1,2-right caudate nucleus-right thalamic circuit existed in 0CD group.Conclusion The left supramarginal gyrus-bilateral cerebellum feet 1 area-right thalamic circuit and left supramarginal gyrus-bilateral cerebellum feet 1,2-right caudate nucleus-right thalamic circuit may play an important role in the mechanism of OCD.
