The research progress of Alzheimer's disease based on gray matter volume and cerebral blood flow

VernacularTitle:阿尔茨海默病基于灰质体积和脑血流量的研究进展
Author: Chang TAN ¹ ; Aiyu LIU ; Yuting SU ; Chunming XIE ; Zhijun ZHANG
Author Information

1. 东南大学附属中大医院神经内科
Keywords: Alzheimer's disease; Magnetic resonance imaging; Gray matter volume; Cerebral blood flow
From: Chinese Journal of Behavioral Medicine and Brain Science 2019;28(1):91-94
CountryChina
Language:Chinese
Abstract: In recent years,magnetic resonance imaging (MRI) has been widely used in the early diagnosis as well as long-term follow-up study of Alzheimer's disease (AD).The studies were reviewed which applied the structural MRI and arterial spin labeling MRI (ASL-MRI) in AD over the past 20 years,and found more gray matter volume loss in multiple brain structures in individuals with AD spectrum.Among them,medial temporal lobe atrophy and posterior cortical atrophy are the most diagnostic.Meanwhile,cerebral blood flow changes in various brain regions with the progression of the AD.More investigations combining the changes of gray matter volume and cerebral blood flow to explore pathophysiological mechanisms underlying cognitive decline in AD spectrum are necessary in the future.