Study on rapid eye movement sleep behavior disorder in patients with Parkinson disease psychosis
10.3760/cma.j.issn.1674-6554.2019.01.011
- VernacularTitle:帕金森病精神病性障碍患者快速眼动睡眠行为障碍研究
- Author:
Gaiqing YANG
1
;
Zhiqiang XU
;
Lixia XU
;
Dongya ZHANG
;
Xiaoyi ZHANG
;
Jiaojiao JIANG
;
Lihong FENG
Author Information
1. 郑州大学附属郑州中心医院神经内科 450000
- Keywords:
Parkinson disease;
Parkinson disease psychosis;
Rapid eye movement sleep behavior disorder;
Polysomnography
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the sleep structure characteristics and risk factors in patients with Parkinson disease psychosis (PDP).Methods Fifty-one patients with Parkinson disease were enrolled.Sixteen cases met the diagnostic criteria of Parkinson disease psychosis were included in the PDP group,while the remaining 35 cases were included in the PD group as the control group.Sleep status was monitored by polysomnography.Neuropsychological assessment of patients with Parkinson disease was performed by Parkinson quality of life questionnaire,Montreal cognitive assessment(MoCA)and Hoehn-Yahr state (H-Y) of Parkinson disease.Results There were statistically significant differences in age of onset in PD group and PDP group (64.11±8.87,57.44±10.07,t=1.242),course of disease (2 (1,4),6 (4,7),Z=-3.888),HY stage (2 (1.5,2.5),3 (2,3),Z=-2.487)(all P＜0.05).The total sleep time in the PDP group was lower than that in the PD group ((344.06±26.39)min,(361.74± 17.16)min,P＜0.05).Compared with the PD group,the proportion of slow wave sleep phase Ⅰ in the PDP group was bigger ((42.88 ± 7.99) ％,(37.14±5.21) ％,t=-3.065),and the proportion of slow wave sleep phase Ⅱ in the PDP group was smaller ((31.19±5.92) ％,(37.51±5.70) ％,t=3.634) (P＜0.05).Single factor binary logistic regression analysis showed that the course of disease,age of onset,RBD,HY stage,PDQ-39 questionnaire score,total sleep time,slow wave sleep stage Ⅰ (％) and slow wave sleep stage Ⅱ (％) were the risk factors of PDP (P＜0.05).Multivariate binary logistic regression analysis showed that the course of disease and RBD were independent risk factors for patients with PDP (P＜ 0.05).Conclusion Sleep structure changes in patients with PDP,and RBD is the independent risk factor for patients with Parkinson's psychotic disorders.
