Cognitive function in patients with early onset and adult onset schizophrenia
10.3969/j.issn.1000-6729.2019.03.001
- VernacularTitle:早发型与成人型精神分裂症患者的认知功能
- Author:
Bingjie HUANG
1
;
Jiaheng XIE
;
Chengcheng PU
;
Huining GUO
;
Lei YANG
;
Xue HAN
;
Zhang CHENG
;
Yanbo YUAN
;
Jingping ZHAO
;
Chuanyue WANG
;
Zheng LU
;
Fude YANG
;
Hong DENG
;
Chuan SHI
;
Xin YU
Author Information
1. 北京大学第六医院
- Keywords:
first episode schizophrenia;
age of onset;
cognition disorders
- From:
Chinese Mental Health Journal
2019;33(3):161-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics of cognitive function in patients with early onset and adult onset schizophrenia.Methods:In this cross-sectional study, 546 patients with schizophrenia who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ) were selected.Among them, 62 cases were defined as early onset schizophrenia (EOS, age of onset＜18 years) and 175 patients were defined as adult onset schizophrenia (AOS, age of onset≥25 years).Patients underwent clinical assessments with the Positive and Negative Symptom Scale (PANSS) and the Personal and Social Performance Scale (PSP), and comprehensive neuropsychological assessments.Results:The EOS patients got lower scores in motor function-PEGDOM T score [ (26±12) vs. (30±11), P＜0.01], working memory-average T score of PASAT and WMSSP[ (34±12) vs. (38±10), P＜0.05]and executive function (inhibition) -Stroop T score [ (35±12) vs. (39±10), P＜0.05]than AOS patients.No differences were fund in processing speed, verbal memory and learning, visual memory and learning (Ps＞0.05) between the two groups.Conclusion:It suggests that the EOS patients have worse motor function, working memory and inhibition.
