Role of group 3 innate lymphoid cells in intestinal barrier

VernacularTitle:3型天然淋巴细胞在肠道屏障中的作用
Author: Zhenliang WEN ¹ ; Dechang CHEN ; Jinjun BIAN
Author Information

1. 海军军医大学(第二军医大学)附属长海医院麻醉学部
Keywords: Intestinal barrier; Group 3 innate lymphoid cell; Intestinal immunity
From: Chinese Critical Care Medicine 2019;31(2):252-256
CountryChina
Language:Chinese
Abstract: Intestinal?barrier?act?as?the?crucial?defender?against?pathogen?invasion,?and?is?indispensable?in?maintaining?tissue?homeostasis?both?locally?and?systemically.?Severe?disease?can?lead?to?impaired?intestinal?barrier.?In?addition?to?cause?a?variety?of?gastrointestinal?diseases,?intestinal?barrier?damage?can?also?worsen?the?disease?progression?in?critically?ill?patients.?Innate?lymphoid?cells?(ILCs)?is?a?group?of?newly?defined?innate?immune?cells?which?have?some?characteristics?as?adaptive?immune?cells.?Group?3?innate?lymphoid?cells?(ILC3),?which?mainly?reside?at?gut?associate?mucosal?tissue,?have?been?reported?to?play?a?critical?role?in?maintaining?intestinal?barrier?function.?After?a?brief?introduction?about?its?origination?and?classification,?we?will?focus?on?function?of?ILC3?physiologically?and?pathologically,?and?provide?a?new?theoretical?basis?for?maintaining?intestinal?barrier?function?under?pathological?conditions?in??this?review.