The role of nicotinamide-adenine dinucleotide phosphate oxidase NOX family in acute lung injury

VernacularTitle:还原型辅酶Ⅱ氧化酶NOX家族在急性肺损伤中的作用
Author: Dan LI ¹ ; Zhukai CONG ; Xiangpeng LYU ; Changyi WU ; Yifan TAO ; Xi ZHU
Author Information

1. 北京大学第三医院危重医学科??100191
Keywords: Acute lung injury; Blood-air barrier; Reactive oxygen species; Nicotinamide-adenine dinucleotide phosphate oxidase
From: Chinese Critical Care Medicine 2019;31(2):244-247
CountryChina
Language:Chinese
Abstract: Acute?lung?injury?(ALI)?and?its?severe?form,?acute?respiratory?distress?syndrome?(ARDS),?are?common?critical?syndromes.?The?causes?of?the?syndrome?are?complex?and?diverse.?The?main?pathological?features?are?the?diffuse?inflammatory?and?protein-rich?pulmonary?edema?caused?by?destruction?of?the?blood-air?barrier.?Reactive?oxygen?species?(ROS)?mediate?oxidative?damage?by?oxidizing?bio-macromolecules,?including?lipids,?proteins?and?nucleic?acid.?Among?many?systems?producing?ROS,?nicotinamide-adenine?dinucleotide?phosphate?(NADPH)?oxidase-mediated?ROS?is?the?main?source,?and?its?functional?subunit?is?the?transmembrane?subunit?NOX?family.?The?distribution?of?NOX?family?proteins?in?lung?tissue?is?cell?type?dependent.?NOX-derived?ROS?is?involved?in?the?defense?function?of?lung?tissue?and?related?to?the?occurrence?and?development?of?ALI/ARDS.?This?review?mainly?describes?the?cell?distribution,?activation?factors,?and?its?relationship?with?the?occurrence?and?development?of?ALI?of?the?NOX?family.