Role of deacetylase sirtuins in sepsis: beneficial or harmful?
10.3760/cma.j.issn.2095-4352.2019.01.006
- VernacularTitle:去乙酰化酶sirtuins在脓毒症中的作用:有利还是有害?
- Author:
Lulan LI
1
;
Zhongqing CHEN
;
Kesen ZHAO
;
Zhenhua ZENG
Author Information
1. 南方医科大学南方医院重症医学科
- Keywords:
Deacetylase sirtuin;
Sepsis;
Network regulation;
Immunosuppression
- From:
Chinese Critical Care Medicine
2019;31(1):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis,life-threatening organ dysfunction caused by a dysregulated host response to infection,is a major public health concern.To date,the mechanism of sepsis is not completely understood,which is still a huge task ahead of numerous clinical and laboratory researchers.Recently,increasing evidences show that deacetylase sirtuins play an important role in sepsis and the function of sirtuins are varied in different stages of sepsis.More importantly,the mechanism of sirutins is not fully understood.The sirtuins family is composed by sirtuin 1-7 members.Among them,sirtuin 1 is widely reported.In addition to sirtuin 1,other members of sirtuins are also involved in the regulation of inflammation or metabolism signaling following sepsis.Of note,the sirtuins may interact with each other and form a precious control mechanism.Herein,we tried to summarize the recent paper from PubMed,to explain the possible mechanism of distinct role of sirtuin 1/2,to generalize the downstream effects of sirtuin 3 action,and to describe the interactions among sirtuins members on sepsis,which might be helpful for our future research and potential clinical applications.
