Effects of low glycemic index cereals on metabolomics and pregnancy outcomes in women with gestational diabetes mellitus
10.3760/cma.j.issn.1674-635X.2018.06.002
- VernacularTitle:低血糖指数谷物对妊娠糖尿病孕妇代谢组学及妊娠结局的影响
- Author:
Huimin CHEN
1
;
Xihong LIU
;
Zhongjie ZOU
;
Jing SUN
;
Jinhui WU
;
Minhua XIAO
Author Information
1. 510623,广州市妇女儿童医疗中心临床营养科
- Keywords:
Glycemic index;
Gestational diabetes mellitus;
Metabolomics;
Pregnancy outcomes
- From:
Chinese Journal of Clinical Nutrition
2018;26(6):331-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low GI cereals on metabolomics and pregnancy outcomes in women with gestational diabetes mellitus (GDM),in order to explore the preventive and therapeutic mechanisms and provide the basis for nutritional interventions.Metbods Pregnant women with gestational diabetes were assigned to the treatment group (n=31),using low GI grains 12 weeks for nutrition intervention and the control group (n =31) according to the random digital table method;30 healthy pregnant women were enrolled as normal control group.At 36th gestational week serum was analyzed by 1H-NMR metabolomics approach.Pregnancy outcomes were gathered for statistics after delivery.Comparison among groups and related influencing factors analysis were conducted.Results After nutritional intervention for 12 weeks,there were statistically significant differences in 15 potential biomarkers associated with gestational diabetes between the treatment group and the control group (P＜0.05),and no statistically significant difference between the treatment group and the normal control group (P＞0.05),that was the pregnant women in the treatment group were close to normal pregnant women.Cesarean rate,gestational weight gain,glycosylated hemoglobin during delivery,fasting insulin and newborn birth weight were significantly lower in the treatment group than in the control group.Multiple linear regression analysis showed that the GI of diet,fasting insulin and blood glucose were influencing factors for metabolomics in women with GDM.Conclusions Using low GI cereals intervention treatments,the pregnancy outcomes of GDM are improved distinctly with the possible mechanisms as adjusting the related biomarkers.Our study provides evidences for further exploring etiology and the therapeutic mechanisms of GDM,and individualized medical nutrition treatment strategy.
