Clinical characteristics and related factors of pneumonia in patients with aplastic anemia
10.16718/j.1009-7708.2019.01.006
- VernacularTitle:再生障碍性贫血患者肺炎的临床特点及相关因素分析
- Author:
Hao XIONG
1
;
Huitao ZHANG
;
Xiaoqing CHEN
;
Yan CHENG
;
Chunlan HUANG
Author Information
1. 西南医科大学附属医院血液内科
- Keywords:
aplastic anemia;
pneumonia;
agranulocytosis;
immunosuppressive therapy
- From:
Chinese Journal of Infection and Chemotherapy
2019;19(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
objective To analyze the clinical characteristics of pneumonia in patients with aplastic anemia for improving early prevention and clinical diagnosis. Methods A retrospective analysis was conducted for patients with aplastic anemia treated in our hosipital from June 2013 to April 2018. The clinical data of pneumonia were reviewed and analyzed in terms of radiological findings, pathogen distribution, and related risk factors. Results The clinical manifestations are atypical in patients with aplastic anemia. The imaging findings suggested that the infection was mainly bilateral pulmonary infection. The common pathogens were gram-negative bacteria such as Klebsiella pneumoniae. Disease type, agranulocytosis and low serum albumin level were independent risk factors for pneumonia in patients with aplastic anemia. Regular immunosuppressive therapy is a protective factor for pneumonia in patients with aplastic anemia. Conclusions The clinical manifestations of pneumonia are diverse in patients with aplastic anemia. The pathogens are mainly gram-negative bacteria. Empirical use of β-lactam-β-lactamase inhibitor combinations or quinolones is beneficial for controlling infection. Regular immunosuppressive therapy, recovery of hematopoietic function, nutritional support are effective measures to reduce the incidence of pneumonia in patients with aplastic anemia.
