Prediction by intravascular ultrasound with monocyte to high density lipoprotein-cholesterol ratio of prognosis in patients with intermediate non-left main coronary lesions underwent percutaneous coronary intervention
10.3969/j.issn.1004-8812.2019.01.010
- VernacularTitle:血管内超声联合单核细胞/高密度脂蛋白胆固醇比值对非左主干临界病变患者行经皮冠状动脉介入治疗预后的评估
- Author:
Qi LI
1
;
Liang-Hong YING
;
Jiang-Jin LI
;
Qing ZHANG
;
Xiaoyi TIAN
;
Shu-Ren MA
;
Xi-Wen ZHANG
;
Zhen LI
Author Information
1. 南京医科大学第一附属医院心内科
- Keywords:
Intermediate coronary lesion;
Intravascular ultrasound;
Monocyte to high density lipoprotein-cholesterol ratio;
Percutaneous coronary intervention
- From:
Chinese Journal of Interventional Cardiology
2019;27(1):45-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prediction by intravascular ultrasound (IVUS) with monocyte to high density lipoprotein-cholesterol (HDL-C) ratio (MHR) of 12-month prognosis in patients with intermediate non-left main coronary lesions after percutaneous coronary intervention (PCI). Methods Patients with intermediate non-left main coronary lesions diagnosed by coronary angiography were tested of monocyte counts and HDL-C levels at admission with MHRs calculated. IVUS was used to examine plaque stability in target lesions. Patients were dviided into stable plaque group (n=44) and unstable plaque group (n=140) according to the IVUS results. PCI was then operated in patients with unstable plaque or with minimum lumen area<4 mm2. The major adverse cardiovascular events (MACE) were recorded during the follow-up period of 12 months after PCI. Results MHR was significantly higher in unstable plaque group than that in stable plaque group[(22.6±8.4) vs.(14.1±7.2),P<0.001]. Receiver-operating characteristic (ROC) analysis revealed that an MHR cut-off of 16.05 had 74.2％ sensitivity and 77.0％ specificity for prediction of 12-month MACE after PCI (AUC 0.78, 95％ CI 0.71–0.85, P<0.001). Besides, unstable plaque with MHR over 16.05 was an independent risk factor for 12-month MACE after PCI (adjusted HR 3.26, 95％ CI 2.48–4.14, P=0.020). Conclusions IVUS combined with MHR is a valuable index predicting the prognosiso f patients with intermediate non-left main coronary lesions who underwent PCI.
