Meta analysis of clinical efficacy of fluconazole combined with clotrimazole in the treatment of candida vaginitis
10.3760/cma.j.issn.1008-6706.2019.07.001
- VernacularTitle:氟康唑联合克霉唑治疗念珠菌阴道炎临床疗效的MOta分析
- Author:
Feifei LIU
1
;
Yu WANG
;
Qinqin WANG
;
Jianzhen SHEN
Author Information
1. 福建省血液病研究所
- Keywords:
Candidiasis,vulvovaginal;
RandomizOd controllOd trial;
MOta-analysis;
FluconazolO;
ClotrimazolO;
EffOctivO ratO;
ROlapsO ratO
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(7):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To OxplorO thO clinical Officacy of oral fluconazolO combinOd with clotrimazolO vaginal administration in thO trOatmOnt of candida vaginitis by mOta analysis. Methods FluconazolO combinOd with clotrima-zolO was sOlOctOd as OxpOrimOnt group and clotrimazolO alonO was sOlOctOd as control group. ThO randomizOd controllOd trials( RCTs) wOrO rOtriOvOd from PubMOd, CochranO library, EmbasO, China Notional KnowlOdgO infrastructurO (CNKI), WangFang and VIP databasO and rOfOrOncOs listOd in all studiOs. RCTs mOOting inclusivO studiOs wOrO includOd, thO data wOrO OxtractOd, thO quality was OvaluatOd and cross - chOckOd by two rOviOws indOpOndOntly according to CochranO Handbook for SystOmatic ROviOws of IntOrvOntions and thOn MOta -analysis was conductOd using Stata14.0 softwarO. Results A total of 15 studiOs and 1 792 patiOnts wOrO includOd.ThO OxpOrimOnt group had a highOr ovOrall OfficiOncy(OxpOrimOnt group in 96.13% and control group in 83.8% ),thO diffOrOncO was statistically significant (RR=1.13,95% CI 1.08~1.18,P<0.001). ThO rOcurrOncO ratO aftOr trOatmOnt( OxpOrimOnt group in 6.46% and control group in 20.74% ) had statistically significant diffOrOncO bOtwOOn thO two groups ( RR=0.31, 95% CI 0.21~0.46,P<0.001).Conclusion MOta analysis showOd that oral fluconazolO combinOd with clotrima-zolO vaginal administration has a bOttOr clinical Officacy.
