Two Cases of Wernicke's Encephalopathy That Developed during Total Parenteral Nutrition in Colon Cancer Patients Treated with 5-Fluorouracil-based Chemotherapy.
10.4166/kjg.2014.64.3.158
- Author:
Kyung Pyo CHO
1
;
Jae Sung LEE
;
Ji Seok SEONG
;
Yong Moon WOO
;
Young Jun CHO
;
Beom Jin JEONG
;
Jee Hoon SOHN
;
Su Jung KIM
Author Information
1. Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
- Publication Type:Case Reports ; English Abstract
- Keywords:
Wernicke encephalopathy;
Thiamine;
Total parenteral nutrition;
Fluorouracil;
Colonic neoplasms
- MeSH:
Adult;
Antimetabolites, Antineoplastic/*therapeutic use;
Brain/radiography;
Colonic Neoplasms/*drug therapy;
Fluorouracil/*therapeutic use;
Humans;
Magnetic Resonance Imaging;
Male;
Middle Aged;
Parenteral Nutrition, Total;
Thiamine/therapeutic use;
Vitamin B Complex/therapeutic use;
Wernicke Encephalopathy/*diagnosis/drug therapy
- From:The Korean Journal of Gastroenterology
2014;64(3):158-163
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Wernicke's encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration.
