Influence of montmorillonite powder combined with racecadotril granules on serum IL-2,IL-6,IL-10 and hs-CRP levels in children with rotavirus enteritis
10.3760/cma.j.issn.1008-6706.2019.03.017
- VernacularTitle:蒙脱石散联合消旋卡多曲对轮状病毒肠炎患儿血清白细胞介素2、6、10及高敏C反应蛋白水平变化的影响
- Author:
Zhuibo YU
1
;
Xiaoqiao LYU
;
Pan LIU
Author Information
1. 浙江省浦江县人民医院药剂科 322200
- Keywords:
Montmorillonite powder;
Racecadotril granules;
Rotavirus enteritis;
High-sensitivity C-reactive protein;
Interleukin;
Safety
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(3):319-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of montmorillonite powder combined with racecadotril granules on serum levels of interleukin-2 (IL-2),interleukin-6 (IL-6),interleukin-10 (IL-10) and high-sensitivity C-reactive protein (hs-CRP) in children with rotavirus enteritis.Methods From June 2014 to July 2016,76 children with rotavirus enteritis in the People's Hospital of Pujiang County were selected and randomly divided into control group and study group according to the digital table,with 38 cases in each group.The two groups were given basic treatment after admission,on the basis,the control group was treated with montmorillonite powder,and the study group was treated with montmorillonite powder combined with racecadotril granules.The two groups were treated for 3 days.The clinical efficacy,clinical symptoms (stool,stool frequency,dehydration,vomiting,fever) recovery time,serum IL-2,IL-6,IL-10 and hs-CRP levels at admission and after treatment,and the incidence of adverse reactions were statistically compared between the two groups.Results The clinical efficacy of the study group (mild constipation,rash,nausea) was better than the control group[19 cases(50.00％) vs.11 cases(28.95％),16 cases(42.11％)vs.15 cases(39.47％),3 cases(7.89％) vs.12 cases(31.58％)],the difference was statistically significant(Z =2.358,P ＜ 0.05).The recovery time of stool character[(45.58 ± 10.11) h],stool frequency [(44.96 ± 10.03) h],dehydration[(33.15 ± 10.27)h],vomit[(18.16 ±6.46)h],and fever[(25.51 ± 10.32)h]of the study group were less than those of the control group(t =9.618,8.344,8.557,3.921,9.487,all P ＜ 0.05).The serum levels of IL-2,IL-6,IL-10 and hs-CRP before treatment between the two groups had no statistically significant differences (all P ＞ 0.05).After treatment,the serum levels of IL-2 and IL-10 in the study group were higher than those in the control group,the serum levels of IL-6 and hs-CRP were lower than those in the control group,the differences were statistically significant(t =5.545,7.705,7.090,10.352,all P ＜ 0.05).The incidence rate of adverse reactions between the study group and the control group had no statistically significant difference(10.52％ vs.13.15％,x2 =0.000,P ＞ 0.05).Conclusion Montmorillonite powder combined with racecadotril granules in the treatment of rotavirus enteritis can effectively relieve the clinical symptoms,improve the serum inflammatory factors level,reduce the inflammatory reaction in vivo,improve the therapeutic effect and has high safety.
