Clinical effect of ibuprofen on preventing intracranial hemorrhage in premature infants and its influence on NT-proBNP and ET-1 level
10.3760/cma.j.issn.1008-6706.2019.03.014
- VernacularTitle:布洛芬预防早产儿颅内出血的临床效果及对氨基末端脑钠肽前体、血浆内皮素水平影响
- Author:
Haihua JIN
1
;
Hongping LU
Author Information
1. 浙江省台州医院新生儿科 317000
- Keywords:
Premature;
Intracranial hemorrhage;
Ibuprofen;
NT-proBNP;
ET-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(3):307-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of ibuprofen on preventing intracranial hemorrhage in premature infants and its influence on the levels of NT-proBNP and ET-1.Methods From January 2016 to December 2017,112 premature infants in Taizhou Hospital were selected as study objects after screening by inclusion and exclusion criteria.The infants were randomly divided into observation group and control group according to the digital table,with 56 cases in each group.The control group was treated with routine therapy,and the observation group was given ibuprofen prophylaxis.The incidence of intracranial hemorrhage,clinical index and serum NT-proBNP,ET-1 levels were compared between the two groups.Results There was significant difference in the incidence rate of intracranial hemorrhage between the observation group (17.86％) and the control group (30.36％)(x2 =12.472,P ＜0.05).The serum levels of NT-proBNP and ET-1 in the observation group were significantly lower than those in the control group(all P ＜ 0.05).There were no statistically significant differences in liver function,renal function,coagulation abnormality and oliguria between the two groups (all P ＞ 0.05).There were no statistically significant differences in feeding intolerance and gastric hemorrhage between the two groups (all P ＞ 0.05).Conclusion The application of ibuprofen suspension can effectively prevent intracranial hemorrhage in premature infants,which is worthy of clinical use.
