Clinical value of C-reactive protein combined with coagulation test in the diagnosis of neonatal late-onset sepsis
10.3760/cma.j.issn.1008-6706.2019.03.011
- VernacularTitle:C-反应蛋白联合凝血功能检测对于新生儿晚发型败血症诊断价值探讨
- Author:
Haiying LAN
1
;
Xiaoxia TAN
;
Junsheng LI
;
Linli WANG
Author Information
1. 浙江省
- Keywords:
Sepsis,late-onset;
C-reactive protein;
Prothrombin time;
Activated partial thrombin time;
Neonatal;
Sensitivity;
Specificity;
Positive predictive value;
Negative predictive value
- From:
Chinese Journal of Primary Medicine and Pharmacy
2019;26(3):294-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of C-reactive protein (CRP) combined with prothrombin time (PT) and partially activated thromboplastin time (APTY) in the diagnosis of neonatal late-onset sepsis.Methods From January 2013 to January 2018,100 neonates with sepsis admitted to our department of neonatology in Lishui Maternal and Child Health-Care Center were collected.According to the results of blood culture,neonates with positive blood culture were classified as sepsis group A (53 cases),and neonates with negative blood culture were classified as sepsis group B (47 cases).Another 50 normal newborns born at the same period were included in the control group.The CRP,PT and APTT values of the three groups were detected and compared.The receiver-operating characteristic curves (ROC) were plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value and negative predictive value.Another ROC curve was plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value,and negative predictive value for a new variable,CPR + PT + APTT,which was established using a binomial logistic regression method.Results The results of CPR,PT and APTT in the control group,sepsis group A and sepsis group B all increased in turn (F=10.616,6.155,5.243,P =0.000,0.000,0.000).CPR + PT + APTT had the largest AUC (0.94),the highest sensitivity (93.42％),the highest specificity (91.66％),the highest positive predictive value (92.60％),and the highest negative predictive value (78.55％) in the four indicators.Conclusion When blood culture fails to diagnose late-onset neonatal sepsis,combined detection of CPR + PT + APTT can provide some clues for its early diagnosis,which is worthy of clinical attention.
