Effect of relatively closed environment dispensing new mode on insoluble particles in pharmaceuticals
10.12138/j.issn.1671-9638.20193707
- VernacularTitle:相对密闭环境配药新模式对药品中不溶性微粒的影响
- Author:
Cui-Jun YAO
1
;
Shu-Mei SUN
;
Ya-Li ZHANG
;
Jia-Jin CHEN
;
Miao-Miao LOU
;
Hao ZHOU
Author Information
1. 南方医科大学南方医院感染管理科
- Keywords:
dispensing;
insoluble particle;
hospital environment
- From:
Chinese Journal of Infection Control
2019;18(3):232-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of relatively closed environment dispensing mode on insoluble particles in pharmaceuticals.Methods The numbers of insoluble particles in conventional manual dispensing mode and relatively closed environment dispensing mode in lass Ⅰ and class Ⅲ environment were detected, effect of different dispensing modes on the number of insoluble particles in pharmaceuticals was compared.Results When adopting manual dispensing, the numbers of 1-10 μm insoluble particulates in different groups in class Ⅰ environment were less than those in class Ⅲ environment respectively, differences were all statistically significant (all P＜0.05). When adopting a new mode of dispensing in relatively closed environment, there was no significant difference in the numbers of 1-15 μm insoluble particulates in different groups between class Ⅰ and class Ⅲ environment respectively (all P＞0.05). The numbers of 1-20 μm and 1-15 μm insoluble particles in different groups were less than those in manual dispensing when the new mode of dispensing were adopted in class Ⅲ and class Ⅰenvironment respectively, differences were all statistically significant (all P＜0.05). The numbers of 1-15 μm insoluble particles in different groups in manual dispensing in class Ⅰ environment were more than those in class Ⅲ environment respectively, difference were all statistically significant (all P＜0.05).Conclusion The relatively closed environment dispensing mode can effectively reduce environmental particulates entering intravenous infusion system during dispensing process.
