Risk factors for healthcare-associated pneumonia caused by carbapenem-resistant Enterobacter cloacae in patients in intensive care unit
10.12138/j.issn.1671-9638.20194256
- VernacularTitle:ICU患者发生耐碳青霉烯类阴沟肠杆菌医院获得性肺炎的危险因素
- Author:
Jing LI
1
;
Yan-Jing WANG
;
Yan-Jiao HE
;
Meng LU
Author Information
1. 哈励逊国际和平医院感控处
- Keywords:
Enterobacter cloacae;
carbapenem-resistant Enterobacter cloacae;
carbapenem resistance;
healthcare-associated pneumonia;
risk factor
- From:
Chinese Journal of Infection Control
2019;18(2):163-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore risk factors for healthcare-associated pneumonia (HAP) caused by carbapenemresistant Enterobacter cloacae (CREC) in patients in intensive care unit (ICU).Methods From July 2013 to June 2017, 64 patients with CREC-HAP in ICU of a hospital were collected as case group, and 64 patients with carbapenem-sensitive Enterobacter cloacae HAP (CSEC-HAP) were as control group, risk factors for the occurrence of CREC-HAP were analyzed retrospectively by 1∶1 matched case-control study.Results Univariate analysis showed that APACHE II score≥20, long length of ICU stay, use of ventilator, long length of ventilator use, use of carbapenems, long duration of antimicrobial use, and at least 2 kinds of antimicrobial agents combined use were associated with the occurrence of CREC-HAP (all P＜0.05).Multivariate logistic regression analysis showed that APACHE II score≥20, use of ventilator, long length of ventilator use, use of carbapenems, and long duration of antimicrobial use were independent risk factors for occurrence of CREC-HAP (all P＜0.05).Conclusion Risk factors for occurrence of CREC-HAP in ICU patients include the use of carbapenems, long length of ventilator use, long duration of antimicrobial use, and APACHE II score≥20.Effective preventive and control measures can be formulated and taken in view of the above risk factors.
