Clinical analysis on death cases of visceral leishmaniasis
10.12138/j.issn.1671-9638.20194143
- VernacularTitle:内脏利什曼病死亡病例的临床分析
- Author:
Xiao-Li LI
1
;
Fei WANG
;
Lei WANG
;
Xiao-Yan ZHENG
;
Min-Jun HUANG
;
Jing-Jing LI
;
Yong-Gen JIA
;
Yang ZOU
Author Information
1. 首都医科大学附属北京友谊医院 北京热带医学研究所热带病防治研究北京市重点实验室
- Keywords:
visceral leishmaniasis;
leishmania;
hypoproteinemia;
hyponatremia;
prognosis
- From:
Chinese Journal of Infection Control
2019;18(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the clinical characteristics and changes in laboratory indicators of patients died of visceral leishmaniasis (VL).Methods Clinical data of 4 patients died of VL in Beijing Friendship Hospital from January 2013 to June 2018 were analyzed, differences in laboratory indicators were compared.Results Disease course of 4 cases of VL ranged from3 to 12 months, all patients had multiple organ damage, including 3 cases with hepatomegaly and splenomegaly, 2 cases with central nervous system damage.IgG antibodies of leishmania were positive in 4 patients, Leishman-Donovan body was found in bone marrow smears.Routine peripheral blood test results in 4 patients decreased significantly, albumin decreased significantly and globulin increased;level of serum sodium ion in 4 patients was lower than 135 mmol/L.Conclusion Long disease course, multiple organ damage, involvement of central nervous system, significant reducing in peripheral blood routine test results, hypoproteinemia, and hyponatremia in patients with VL all indicate poor prognosis and high mortality.
