Species distinction in scarless healing of myocardial injury and major influencing factors
10.3760/cma.j.issn.2095-4255.2019.04.022
- VernacularTitle:心肌损伤无疤痕愈合能力的物种差异及主要影响因素
- Author:
Feng CHEN
1
;
Min ZHANG
;
Junfan LI
;
Jia HOU
;
Shuqiu SUN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所 150081
- Keywords:
Heart failure;
Cardiac regenerative capacity;
Species;
Influential factors
- From:
Chinese Journal of Endemiology
2019;38(4):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is the leading cause of death in cardiovascular diseases.Despite effectiveness of current clinical treatment,it is not satisfactory in general,so more effective and optimal therapies are under seeking.All available evidences show that cardiac muscles have limited regenerative capacity in adult mammals,while some vertebrates,such as zebrafish and salamander,can completely recover through perfect regeneration following myocardial injury.In-depth investigation into underlying mechanism may facilitate the development of human heart's potential of scarless healing.In this review paper,we summarized recent progresses in distinct cardiac regenerative capacity and their main influencing factors of several model animals through comparative analysis.
