Progress of STIM1, a dynamic calcium signal transducer, in cardiovascular diseases
10.3969/j.issn.1000-4718.2019.02.031
- VernacularTitle:钙传感器基质交感分子1与心血管疾病的研究进展
- Author:
Fang-Yuan LIU
1
;
Nan TANG
;
Zheng YANG
;
Di FAN
;
Qi-Zhu TANG
Author Information
1. 武汉大学人民医院心血管内科
- Keywords:
Calcium ion;
Store-operated calcium channel;
Stromal interaction molecule 1;
Cardiovascular diseases
- From:
Chinese Journal of Pathophysiology
2019;35(2):379-384
- CountryChina
- Language:Chinese
-
Abstract:
Stromal interaction molecule 1 (STIM1) is a transmembrane protein of the endoplasmic reticulum (ER) , a Ca2+ transducer in ER that activates the store-operated calcium channel.Through Orai1 protein, STIM1 adjusts the intracellular and extracellular calcium concentration.This way is called a store-operated Ca2+ entry.STIM1 plays a key role in phenotypic transformation of vascular smooth muscle cells, proliferation of endothelial cells, myocardial hypertrophy and myocardial fibrosis to regulate lots of cardiovascular diseases, such as atherosclerosis, congestive heart failure and systemic hypertension.STIM1 is closely related to cardiovascular diseases through calcium signal.The research progress of STIM1 in cardiovascular diseases is mainly discussed in this article.
