Limit Test of Camphor in Niuhuang Qingxin Pills (Prescription of the Bureau)
10.3870/j.issn.1004-0781.2019.02.021
- VernacularTitle:牛黄清心丸(局方)中樟脑限量检查
- Author:
Lixing NIE
1
;
Zhong DAI
;
Shuangcheng MA
Author Information
1. 中国食品药品检定研究院
- Keywords:
Niuhuang qingxin pills (prescription of the bureau);
Camphor;
Limit test;
Chromagraph,gas
- From:
Herald of Medicine
2019;38(2):235-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish limit test method of camphor in Niuhuang qingxin pills (prescription of the bureau) . Methods The separation was performed on an HP-INNOWAX capillary column (0.25 mm×30 m, 0.25 μm) and the column temperature was 110 ℃ . The temperatures of the inlet and the FID detector were 200 and 230 ℃ , respectively. The flow rate of the carrier gas was 1.8 mL·min-1 and the split ratio was 10:1. The injection volume was 1 μL. Results Good linearity was obtained for camphor within the range of 1.65 to 165 μg·mL-1, and the average recovery of low, medium, high concentration were 99.12％, 99.56％ and 99.56％, respectively,with RSD were 1.01％,0.69％ and 0.38％, respectively. Trace camphor was found in 7 samples out of 38 samples from 9 manufactures. Conclusion The proposed method was accurate, sensitive and simple, and was suitable for quality evaluation and safety control of Niuhuang qingxin pills (prescription of the bureau) .
