Research Progress of Folate Metabolic Gene Polymorphism
10.3870/j.issn.1004-0781.2019.02.020
- VernacularTitle:叶酸代谢基因多态性的研究进展
- Author:
Jing LI
1
;
Linli ZHENG
;
Ting JIANG
;
Ying SHAO
;
Mingyong YUAN
Author Information
1. 成都医学院第一附属医院药学部
- Keywords:
Folic acid;
Methylenetetrahydrofolate reductase;
Methionine synthase reductase;
Gene polymorphism
- From:
Herald of Medicine
2019;38(2):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Through summarizing and analyzing a large number of documents and reports of large academic conferences in China, the current situation and the prospect of individualized drug delivery model were analyzed based on folate metabolic gene in pharmaceutical care. Folate metabolic genemethylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G were related with development of multiple diseases. Its polymorphism guidesindividualized drug administrationto increase the efficacy of drugs or decrease adverse effects.
