Application Progress of Raman Spectroscopy in the Study of Drug Polymorphism
10.3870/j.issn.1004-0781.2019.02.012
- VernacularTitle:拉曼光谱技术在药物晶型研究中应用进展
- Author:
Jian ZHOU
1
;
Shiying YANG
;
Guimin JIN
;
Li ZHANG
;
Yang LYU
Author Information
1. 北京协和医学院中国医学科学院药物研究所晶型药物研究北京市重点实验室
- Keywords:
Raman spectroscopy;
Polymorphism,drug;
Analysis of polymorphism
- From:
Herald of Medicine
2019;38(2):197-202
- CountryChina
- Language:Chinese
-
Abstract:
Different polymorphs of drugs have different molecular arrangements or molecular forces. Raman spectroscopy can reflect the change of molecular polarizability and can be used for the detection of drug polymorphs. The technology has been recorded for the analysis of polymorphism in European Pharmacacopoeia, British Pharamacopoeia and Chinese pharmacopoeia. This review focuses on the application of Raman spectroscopy in the study of pharmaceutical polymorphism. The advances in Raman spectroscopy in the qualitative, quantitative and dynamic processes of drug polymorphism are summarized and analyzed systematically, aiming to provide reference for researchers in related fields.
