Safety Evaluation of Morphine Hydrochloride Injection
10.3870/j.issn.1004-0781.2019.02.004
- VernacularTitle:盐酸吗啡注射液安全性实验评价
- Author:
Wenzhi WEI
1
;
Jichao SUN
;
Conghui ZHU
;
Minjuan ZHANG
;
Tianxue WANG
Author Information
1. 青海省药品检验检测院
- Keywords:
Morphine injection,hydrochloride;
Safety;
Irritation;
Hypersensitivity;
Hemolysis
- From:
Herald of Medicine
2019;38(2):159-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of morphine hydrochloride injection. Methods Ear verin injection was used to evaluate the vascular irritation using the comparison of left side with right side in rabbits. Quadriceps femoris injection was used to evaluate the muscle irritation using the comparison of left side with right side in rabbits. Guinea pigs were intravenously injected with morphine hydrochloride injection at a dose of 2.8 mg·kg-1 once daily 3 times, stimulation was performed on 14 d after the last sensitization and the booster dose was 2 times the sensitization dose. The allergic reactions were observed. The different concentrations of morphine hydrochloride injection were placed in 2％ rabbit erythrocyte suspension, and then the hemolyzation and agglutination were observed. Results There were no significant vascular or muscular irritation and injury effects of morphine hydrochloride injection in rabbits. There were no evidenceof hemolyzation and agglutination in rabbit erythrocytes in vitro. No allergic reactions on guinea pigs in vivo were observed. Conclusion After treatment of morphine hydrochloride injection, neither obvious vascular /muscle stimulation or sensitization, nor hemolyzation or agglutination appeared in rabbits. The research results provide basic reference for the clinical rational and safe application of morphine hydrochloride injection.
