Effects of salidroside on the growth of xenograft tumor of human pancreatic cancer BxPC-3 cells in nude mice
10.3760/cma.j.issn.1674-1935.2019.02.006
- VernacularTitle:红景天苷对人胰腺癌BxPC-3细胞裸鼠移植瘤生长的影响
- Author:
Yubin KOU
1
;
Yunsong LU
;
Xiaoping CHEN
Author Information
1. 上海中医药大学附属曙光医院宝山分院 宝山区中西医结合医院胰胆外科
- Keywords:
Pancreatic neoplasms;
Rhodiola;
Cell proliferation;
Apoptosis
- From:
Chinese Journal of Pancreatology
2019;19(2):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of salidroside on xenograft tumor of human pancreatic cancer cells BxPC-3 in nude mice.Methods BxPC-3 subcutaneous xenograft tumor nude mice model was established,and the mice were randomly divided into control group,salidroside 25 mg group and salidroside 50 mg group using random number method (6 mice in each group).25 mg/kg and 50 mg/kg salidroside by intragastric administration was performed per day for 3 weeks and the tumor was resected.The tumor was weighed and the diameter was measured.Cell apoptosis was detected by Tunel staining.Results As result,tumor weight was (1.561 ± 0.416)g in the control group,(0.742 ± 0.272)g in the 25 mg group and (0.276 ± 0.064) g in the 50 mg group respectively;tumor volume was (2354.35 ± 523.11) mm3,(991.43 ± 348.91) mm3 and (403.60 ± 130.98) mm3,respectively;and the apoptosis rate of the transplanted tumor cells was (23.74 ± 5.88) ％,(49.30 ± 6.75) ％ and (64.97 ± 6.99) ％,respectively,with significant difference among three groups (all P ＜ 0.01).The effect of salidroside on inhibiting proliferation and promoting apoptosis was dose dependent.Conclusions Salidroside can significantly inhibit the proliferation and growth of pancreatic cancer BxPC-3 cells via promoting cell apoptosis and inhibiting cell proliferation.
