Influence of stereotactic body radiation therapy on the survival of patients with early stage pancreatic cancer
10.3760/cma.j.issn.1674-1935.2019.01.006
- VernacularTitle:立体定向体部放射治疗对早期胰腺癌患者生存期的影响
- Author:
Yangyang GENG
1
;
Nilong LIU
;
Xiaofei ZHU
;
Yin TANG
;
Xianzhi ZHAO
;
Huojun ZHANG
Author Information
1. 海军军医大学附属长海医院放疗科
- Keywords:
Pancreatic neoplasms;
Radiotherapy;
Treatment outcome
- From:
Chinese Journal of Pancreatology
2019;19(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of stereotactic body radiation therapy (SBRT) on the survival of patients with early stage pancreatic cancer.Methods The clinical data of 103 T1-2N0M0 pancreatic cancer patients treated by CyberKnife SBRT at the Department of Radiation Oncology of Changhai Hospital from January 2012 to December 2016 was retrospectively analyzed.Kaplan-Meier method was used for survival analysis and Cox proportional hazards model was utilized to identify survival related factors.Results The median overall survival(OS) of T1-2N0M0 pancreatic cancer patients who had unresectable pancreatic cancer or refused surgery was 17.7 (16.1-19.3) months.1-year and 2-year OS rate were 86.3％ and 24.6％,respectively.The median progression free survival(PFS) was 13.0(10.7-15.3) months.1-year and 2-year PFS rate were 54.5％ and 6.3％,respectively.Patients with chemoradiation,BED10 ≥60 Gy and CA19-9 decrease ＞ 50％ after treatment had longer OS and PFS.Conclusions SBRT is a safe and effective treatment for patients with T1-2N0M0 pancreatic cancer.
