Methodology of drug screening and target identification for new necroptosis inhibitors
- Author:
Pengchao PAN
1
;
Zhenyu CAI
;
Chunlin ZHUANG
;
Xiaofei CHEN
;
Yifeng CHAI
Author Information
1. Department of Pharmaceutical Analysis
- Keywords:
Necroptosis;
Inhibitors;
Drug screening;
Target identification;
Review
- From:
Journal of Pharmaceutical Analysis
2019;9(2):71-76
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis has been considered as the only form of regulated cell death for a long time. However, a novel form of programmed cell death called necroptosis was recently reported. The process of necroptosis is regulated and plays a critical role in the occurrence and development of multiple human diseases. Thus, the study on the molecular mechanism of necroptosis and its effective inhibitors has been an attractive field for researchers. Herein, we introduce the molecular mechanism of necroptosis and focus on the literature about necroptosis drug screening in recent years. In addition, the identification of the critical drug targets of the necroptosis is also discussed.
