Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals
- Author:
Yu ZHANG
1
;
Rui ZHANG
;
Xiaolin YANG
;
Honglan QI
;
Chengxiao ZHANG
Author Information
1. Medpace Bioanalytical Laboratories
- Keywords:
Electrogenerated chemiluminescence;
Pharmaceutical analysis;
Immunoassay;
Biosensors
- From:
Journal of Pharmaceutical Analysis
2019;9(1):9-19
- CountryChina
- Language:Chinese
-
Abstract:
Electrogenerated chemiluminescence (electrochemiluminescence, ECL) generates species at electrode surfaces, which undergoes electron-transfer reactions and forms excited states to emit light. It has be-come a very powerful analytical technique and has been widely used in such as clinical testing, bio-warfare agent detection, and pharmaceutical analysis. This review focuses on the current trends of molecular recognition-based biosensing methods for pharmaceutical analysis since 2010. It introduces a background of ECL and presents the recent ECL developments in ECL immunoassay (ECLIA), im-munosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted poly-mers (MIP)-based sensors. At last, the future perspective for these analytical methods is briefly discussed.
