Expression of Parkin protein in colorectal cancer and its clinical significance
10.3760/cma.j.issn.1673-4904.2019.03.009
- VernacularTitle:Parkin蛋白在结直肠癌中的表达及其临床意义
- Author:
Wei XIONG
1
;
Xiaolin WANG
;
Maohui FENG
Author Information
1. 华中科技大学同济医学院附属梨园医院呼吸内科
- Keywords:
Colorectal neoplasms;
Immunohistochemistry;
Parkin protein
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(3):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Parkin protein in colorectal cancer and its clinical significance. Methods Immunohistochemistry was used to detect the expression of Parkin protein in normal and cancerous tissues of 50 patients with colorectal cancer from 2012 to 2015. The relationship between clinicopathological characteristics and Parkin protein expression was analyzed. Results The positive expression rate of Parkin protein in cancerous tissues was significantly lower than that in normal tissues: 36% (18/50) vs. 72% (36/50), and there was statistical difference (P＜0.01). The positive expression of Parkin protein was correlated with the degree of tissue differentiation (P < 0.01);but it was not correlated with sex, age, tumor diameter, tumor type, tumor infiltration, lymph node metastasis and clinical stage (P＞0.05). Conclusions In colorectal cancer tissues, the expression of Parkin gene is absent and decreased. The abnormal expression of Parkin gene may be related to the occurrence and development of colorectal cancer.
