Correlation between serum complement C1q and microalbuminuria in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2019.03.006
- VernacularTitle:血清补体C1q与2型糖尿病患者尿微量白蛋白的相关性研究
- Author:
Dechuan LU
1
;
Congqing MIAO
;
Xinlong MENG
Author Information
1. 扬州大学附属扬州市江都人民医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Complement C1q;
Microalbuminuria
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(3):214-217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum complement C1q and microalbuminuria (MAU) in patients with type 2 diabetes mellitus (T2DM). Methods Two hundred and thirty patients with T2DM from January 2017 to July 2018 were selected. The patients were divided into 3 groups according to the MAU: group A (100 patients with MAU≤30 mg/L), group B (80 patients with 30 mg/L ＜ MAU ≤ 300 mg/L) and group C (50 patients with MAU ＞300 mg/L). The clinical data were recorded and serum complement C1q was measured by immunoturbidimetry. The homeostatic model assessment C-peptide resistance index (HOMA-CR) was calculated. The correlation was analyzed by Spearman correlation analysis, and multivariate Logistic regression analysis was performed with MAU ＞300 mg/L as dependent variable. Results The complement C1q in group C was significantly higher than that in group A and group B: (198.72 ± 43.25) mg/L vs. (173.42 ± 29.36) and (181.57 ± 35.79) mg/L, and there was statistical difference (P＜0.05). Spearman correlation analysis result showed that serum complement C1q had positive correlation with body mass index (BMI), fasting C-peptide (FCP), HOMA-CR and MAU in patients with T2DM (r = 0.22, 0.26, 0.31 and 0.38; P＜0.05). Multivariate Logistic regression analysis result showed that course of disease, glycosylated hemoglobin A1c (HbA1c) and complement C1q were the independent risk factor of MAU＞300 mg/L in patients with T2DM (P＜0.01). Conclusions In patients with T2DM, serum complement C1q has positive correlation with MAU, and it is the independent risk factor of MAU＞300 mg/L. The serum complement C1q may be one of the indicators of large amount of MAU.
