Influence of combined drug therapy by intratracheal infusion on clinical prognosis of premature infants with severe RDS
10.3760/cma.j.issn.1673-4904.2019.02.015
- VernacularTitle:二联支气管药物滴注方案对重症呼吸窘迫综合征早产儿临床预后的影响
- Author:
Lili PING
1
;
Shuyan ZHANG
;
Shufen ZHAI
Author Information
1. 河北省邯郸市中心医院新生儿科 056000
- Keywords:
Pulmonary surfactant;
Glucocorticoid;
Respiratory distress syndrome;
Preterm infants
- From:
Chinese Journal of Postgraduates of Medicine
2019;42(2):154-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of combined drug therapy by intratracheal infusion on clinical prognosis of premature infants with severe respiratory distress syndrome (RDS). Methods One hundred and twenty-eight premature infants with severe RDS were chosen in the period from August 2015 to December 2017 in central hospital of Hebei Handan and randomly divided into 2 groups including control group (64 children) treated with pulmonary surfactant (PS) by intratracheal infusion and experimental group (64 children) treated with PS and budesonide by intratracheal infusion. The invasive ventilation time, withdrawal time, total hospitalization time, the levels of blood oxygen index before and after treatment and the complications incidence of two groups were compared. Results The invasive ventilation time, withdrawal time and total hospitalization time in experimental group were significantly shorter than those in control group:(3.50 ± 0.72) d vs.(4.84 ± 0.98) d, (29.52 ± 3.97) d vs. (35.21 ± 5.10) d, (45.26 ± 6.27) d vs. (53.85 ± 8.04) d, and there were significant differences (P<0.05). The levels of blood oxygen index after treatment of experimental group were significantly better than those of control group (P < 0.05). The incidence of total bronchopulmonary dysplasia(BPD), retinopathy, necrotizing enterocolitis, pulmonary hemorrhage, sepsis, intracranial hemorrhage and ventilator-associated pneumonia (VAP) in two groups had not significant differences (P>0.05). But the moderate to severe BPD in experimental group was significantly lower than that in control group: 15.63％(10/64) vs. 45.31％(29/64), P < 0.05. Conclusions Combinated drug therapy by intratracheal infusion in the treatment of premature infants with severe RDS can efficiently promote disease recovery process, improve the lung function and be helpful to prevent the moderate and severe degree BPD.
