The relation between chemokines and retinal vein occlusion
10.3760/cma.j.issn.2095-0160.2019.03.016
- VernacularTitle:趋化因子与视网膜静脉阻塞的相关性
- Author:
Mingyue LIU
1
Author Information
1. 哈尔滨医科大学附属第一医院眼科医院 150001
- Keywords:
Chemokines;
Retinal vein occlusion;
Interleukin-8;
Monocyte chemotactic protein-1;
Triamcinolone acetonide;
Anti-vascular endothelial growth factor
- From:
Chinese Journal of Experimental Ophthalmology
2019;37(3):238-240
- CountryChina
- Language:Chinese
-
Abstract:
Chemokines are a family of cytokines that induce leukocyte recruitment in inflammation and immune responses.Studies have confirmed that chemokines are associated with retinal vein occlusion (RVO),such as high expression of interleukin-8 (IL-8),monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in the eyes of RVO.Some chemokines,such as MCP-1 and IL-8 can aggravate macular edema and retinal ischemia in patients with RVO.For the treatment of RVO,the application of triamcinolone acetonide (TA) and anti-vascular endothelial growth factor (anti-VEGF) drugs has also been proved to inhibit the expression of some chemokines in the eyes,and the therapeutic effect is correlated with the level of initial chemokines.This article will introduce the research progress on the correlation between chemokines and RVO from the above aspects.
