Research advances on function and molecular mechanism of peroxisome proliferator activated receptors in liver diseases
10.3760/cma.j.issn.1673-9752.2019.04.018
- VernacularTitle:过氧化物酶体增殖物激活受体在肝脏疾病中的作用及分子机制研究进展
- Author:
Panfei MA
1
;
Chaoqun WANG
;
Mingqi GU
;
Yong MA
Author Information
1. 哈尔滨医科大学附属第一医院肝脏外科省部共建教育部肝脾外科重点实验室 150001
- Keywords:
Liver disease;
Peroxisome proliferator activated receptors;
Mechanism;
Research advance
- From:
Chinese Journal of Digestive Surgery
2019;18(4):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator activated receptors (PPARs) are ligand activated nuclear transcription factors and one of the members of the non steroidal nuclear receptor superfamily.It can be divided into PPAR alpha,PPAR beta / delta and PPAR gamma three subtypes according to the different of its structure and function.Previous studies showed that PPARs participated in biochemical reactions and the regulation of other important biological activities such as lipogenesis,glucose metabolism,inflammation,insulin sensitivity and so on.Recent researches showed that PPARs also had effect of anti-fibrosis,protecting ischemia-reperfusion injury and inhibiting the growth and differentiation of tumor cells.This article reviewed the recent research progress of PPARs in these liver diseases.
