Research progress of myocardial scaffolds in the treatment of myocardial infarction
10.3969/j.issn.2095-4344.1639
- VernacularTitle:心肌支架材料在心肌梗死治疗中的应用与研究热点
- Author:
Liang ZHAO
1
;
Xiaona QIU
;
Xiafei LI
Author Information
1. 北京大学工学院
- Keywords:
Myocardial Infarction;
Heart,Artificial;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2019;23(14):2279-2284
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In recent years, myocardial tissue engineering has developed rapidly. By using exogenous biomaterials to simulate extracellular matrix, damaged myocardial cells can be effectively repaired or reconstructed, which has great potential value in the treatment of ischemic heart diseases such as myocardial infarction. OBJECTIVE: To review the research progress of myocardial scaffolds in the treatment of myocardial infarction. METHODS: NCBI and WanFang databases were retrieved for relevant articles published from 2008 to 2018, with the key words of "myocardial scaffold materials, myocardial infarction" in English and Chinese, respectively. RESULTS AND CONCLUSION: At present, the commonly used myocardial scaffolds are mainly natural biomaterials (including collagen/Matrigel, fibrin, chitosan, hyaluronic acid, and algae hydrochloric acid) , synthetic materials (polyester synthetic materials and nanomaterials) and composite scaffolds. Due to the complexity of cardiac environment and heart function, the selection of scaffold materials should fully take account of biocompatibility, immunogenicity, conductivity, degradation rate and susceptibility to ischemia and hypoxia. Although many scaffold designs have begun to meet many requirements, there are still many kinds of stent materials for clinical application. It is believed that with the further development of researchers and application tools, people can expect to create myocardial scaffolds close to the physiological function of the original tissue, so that the heart function can be better restored.
