Allogeneic and xenogeneic tissue repair materials:how to choose a suitable virus inactivation process
10.3969/j.issn.2095-4344.1649
- VernacularTitle:同种异体及异种组织修复材料:如何选用适宜的病毒灭活工艺
- Author:
Yulong BAI
1
;
Yufeng GAO
;
Hongbin ZHONG
;
Yantao ZHAO
;
Ruizhou GUO
;
Li LI
Author Information
1. 解放军总医院第一附属医院骨科
- Keywords:
Biocompatible Materials;
Virus Inactivation;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2019;23(14):2261-2268
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: A proper virus inactivation procedure of medical bio-derived tissue repair material is very important to reduce the risk of virus infection and ensure the safety in the therapeutic process. OBJECTIVE: To elaborate different virus inactivation methods of allogeneic and xenogeneic tissue repair materials. METHODS: PubMed, Elsevier, CNKI, and WanFang databases were searched for relevant articles using the keywords of "allogeneic, xenogeneic, viral inactivation, disinfection, tissue repair biomaterial" in English and Chinese, respectively. RESULTS AND CONCLUSION: Virus inactivation methods can damage the performance of biological materials to different extents. For example, heat inactivation may produce permanent damage to the performance of heat-sensitive materials; γ-ray irradiation may result in the loss of mechanical properties and biologically active substances; acid/alkali method may also destroy the properties and structure of some materials intolerant to acid and alkali corrosion; and some reagent residues such as ethylene oxide, peracetic acid, and hydrogen peroxide may produce irritation to the body and even cause carcinogenic and teratogenic substances. Therefore, in enterprises and research institutions, the virus-killing effect and severity of damage to the material performance should be considered when the virus inactivation process is selected, and the use of existing production processes to verify the virus inactivation is recommended as much as possible.
