Effects of intravenous lidocaine and dexmedetomidine on cough during extubation after endoscopic thyroidectomy
10.3969/j.issn.1006-5725.2019.04.027
- VernacularTitle:静脉输注利多卡因与右美托咪定对腔镜甲状腺手术后拔管期呛咳反应的影响
- Author:
Shenghong HU
1
;
Shengbin WANG
;
Xia JU
;
Siqi XU
;
Jingbo XIAO
Author Information
1. 安徽医科大学附属安庆医院麻醉科
- Keywords:
lidocaine;
dexmedetomidine;
endoscopic thyroidectomy;
coughing
- From:
The Journal of Practical Medicine
2019;35(4):631-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective Comparation of the effects of intravenous lidocaine and dexmedetomidine on coughing during extubation after endoscopic thyroidectomy. Methods 60 patients who underwent endoscopic thyroidectomy were randomly divided into group L, group D and group C, each group included 20 cases. Group L were given a loading lidocaine 1.5 mg/kg over 10 minutes before anesthesia induction, followed by a continuous intravenous lidocaine 1.5 mg/ (kg·h) until 30 min before the end of surgery. Group D were given a loading dexmedetomidine 0.5μg/kg over 10 minutes before anesthesia induction, followed by a continuous intravenous dexmedetomidine 0.4 μg/ (kg · h) until 30 min before the end of surgery. Group C were given intravenous infusion of equal volume normal saline. The incidence and severity of coughing were recorded within 2 minutes after extubation. Hemodynamic variables were measured at T0 (before anaesthesia induction) , T1 (immediately after extubation) , and T2 (5 min after extubation). The volume of drainage was recorded within 24 hours after surgery. Results The incidence and grade of cough were significantly lower in group L and group D than in group C (P < 0.05). Compared with group L and group D, MAP and HR were significantly increased in group C at T1 and T2 (P < 0.05). Compared with group C, the volume of drainage was significantly reduced in group L and group D within 24 hours after surgery (P < 0.05).Conclusion Intravenous lidocaine and dexmedetomidine can effectively inhibit coughing during extubation period after endoscopic thyroidectomy, and there is no significant difference between the two treatments.
