The correlation between the serum resistin and the collapse process of femoral head necrosis
10.3969/j.issn.1006-5725.2019.04.016
- VernacularTitle:抵抗素水平与股骨头坏死塌陷进程的相关性
- Author:
Xiaoming HE
1
;
Shuidi GONG
;
Fengxiang PANG
;
Xiaojun CHEN
;
Weifeng LI
;
Yingshan SHEN
;
Lixin CHEN
;
Fan YANG
;
Shaojun LIU
;
Qiushi WEI
Author Information
1. 广州中医药大学
- Keywords:
osteonecrosis of the femoral head;
resistin;
cartilage;
ARCO stages
- From:
The Journal of Practical Medicine
2019;35(4):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective We aimed to explor the correlation between the serum resistin levels and the collapse process of femoral head necrosis. Methods Eighty-eight patients with osteonecrosis of the femoral head were included in this study (26, 34 and 28 cases at ARCO stage Ⅱ, Ⅲ and Ⅳ, respectively). Fifty healthy controls were enrolled. The serum resistin levels were detected with ELISA method. We compared the serum resistin levels between the patient group and control group. The differences of serum resistin levels between different ARCO stagesand various disease causes were analyzed in the patient group. Results The resistin levels were significantly higher in patients with osteonecrosis of the femoral than healthy control group (P = 0.026). Compared with control group, the resistin levels significantly increased in patients at ARCO stage Ⅲ and ARCO stage Ⅳ respectively (P = 0.001).The resistin levels of procollapse group (ARCO stage Ⅲ and Ⅳ) were significantly higher than that of precollapse group (ARCO stage Ⅱ) (P = 0.000). There was no statistic difference between ARCO stage Ⅲ andⅣ in resistin levels (P> 0.05). No statistical significance was found between different disease causes. ROC curve analysis of resisrin level indicated theertain accuracy (AUC = 0.749) , sensitivity and significant specificity (77.4％, 61.5％, respectively) in the diagnosis of femoral head necrosis. Conclusions Resistin is closely related to the collapse process of femoral head necrosis. The level of resistin was significantly increased after the collapse of femoral head, which could be useful for the clinical diagnosis of the collapse of femoral head necrosis.
