Cytogenetic analysis on 5329 children in genetic counseling
10.3969/j.issn.1006-5725.2019.03.033
- VernacularTitle:5329例遗传咨询儿童细胞遗传学分析
- Author:
Chi ZHANG
1
;
Xijiang HU
;
Ling LIU
;
Pingxia XIANG
;
Pei LENG
;
Lifang NING
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)优生遗传实验室
- Keywords:
genetic counseling;
chromosomal abnormality;
child
- From:
The Journal of Practical Medicine
2019;35(3):479-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between chromosomal abnormalities and diseases in children by analyzing chromosome karyotypes. Methods The chromosome karyotype analysis of peripheral lymphocytes in 5 329 children was performed. Results In all, abnormal karyotype were found in 1 723 cases (32.33％) , in which the numerical chromosome abnormalities were detected in 1 539 (89.32％) , following by 125 cases of structural chromosome abnormalities (7.25％) , 53 cases of sex reverse syndrome (3.08％) , and 6 cases of true hermaphroditism (0.35％). The chromosome polymorphism were detected in 228 cases (4.28％). Conclusions The numerical chromosome abnormalities is most frequent chromosomal aberration and is one of the important causes that result in mental retardation, growth delay and disorders of sex development in children.
