Effect of enhanced external counterpulsation on vascular endothelial diastolic function and plasma LP-PLA2 levels in patients with unstable angina
10.3969/j.issn.1006-5725.2019.03.023
- VernacularTitle:增强型体外反搏对不稳定型心绞痛患者血管内皮舒张功能及血浆脂蛋白磷脂酶A2水平的影响
- Author:
Zhen LIU
1
;
Jiajia ZHAO
;
Junya FAN
;
Zhao ZHANG
;
Miaomiao LIU
;
Hui ZHANG
Author Information
1. 郑州大学第二附属医院
- Keywords:
enhanced external counterpulsation;
unstable angina;
plasma lipoprotein phospholipase A2;
vascular endothelial function
- From:
The Journal of Practical Medicine
2019;35(3):437-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of enhanced external counterpulsation (EECP) on plasma lipoprotein phospholipase A2 (LP-PLA2) levels, vascular endothelial diastolic function in patients with unstable angina. Methods One hundred patients with unstable angina treated in our hospital were randomly divided into routine treatment group (control group n-49) and external counterpulsation group (observation group n = 51, routine treatment plus external counterpulsation therapy, 60 min/time, a total of 30 times). All selected subjects were tested for LP-PLA2 levels on the day of enrollment and on the 30 th day after treatment, and color Doppler ultrasonography was used to detect arterial blood flow-mediated vasodilation (FMD) and nitroglycerin-mediated vasodilation (NMD). Results After treatment in the observation group, LP-PLA2 decreased compared with before treatment, the difference was statistically significant (P < 0.05) , but FMD, NMD were higher than those before treatment, which had statistical difference (P < 0.05). In control group treatment afterwards, LP-PLA2, endothelium-dependent vasodilatation and non-endothelium-dependent vasodilatation did not change significantly before treatment (P> 0.05). Observations between groups showed that the increase in FMD and NMD in the observation group was significantly greater than that in the control group. P < 0.01) , plasma LP-PLA2 levels in the observation group also decreased compared with the control group (P < 0.05). Conclusion Enhanced external counterpulsation can reduce the level of LP-PLA2 in patients and improve endothelial diastolic function under the action of blood flow shear stress.
