Relationship between angiopoietin-2, vascular endothelial growth factor, carbohydrate antigen 199 and carcinoembryonic antigen in the diagnosis and postoperative recurrence and metastasis in colon cancer
10.3969/j.issn.1006-5725.2019.03.021
- VernacularTitle:血管生成素-2、血管内皮生长因子、糖类抗原199及癌胚抗原对结肠癌诊断和复发转移的预测价值
- Author:
Haibo MAO
1
;
Guodong ZHU
;
Runya FANG
;
Baoxiu LI
;
Xisheng FANG
;
Guolong LIU
Author Information
1. 广州市第一人民医院肿瘤科
- Keywords:
angiopoietin-2;
vascular endothelial growth factor;
carbohydrate antigen 199;
carcinoembryonic antigen;
colon cancer
- From:
The Journal of Practical Medicine
2019;35(3):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis of colon cancer patients and the prediction of postoperative recurrence and metastasis in patients with colon cancer by serum angiopoietin-2 (Ang-2) , vascular endothelial growth factor (VEGF) , carbohydrate antigen 199 and carcinoembryonic antigen CEA. Methods 100 patients with colon cancer, 100 patients with benign colonic lesions and 100 healthy subjects were examined. The levels of Ang-2, VEGF, CA19-9 and CEA in serum were detected, and the diagnosis and postoperative recurrence and metastasis of colon cancer were investigated. Results The levels of serum Ang-2, VEGF, CA19-9 and CEA in colon cancer group were higher than those in benign lesions and healthy controls (P < 0.05). The levels of Ang-2, VEGF, CA19-9 and CEA were detected. The sensitivity and specificity of each index were significantly higher in the diagnosis of colon cancer. The preoperative recurrence and metastasis rates of patients with positive Ang-2, VEGF, CA19-9 and CEA were higher than those of the negative patients respectively. Survival analysis showed a statistically significant difference in the time of distant metastasis between different expression states (P < 0.05). Conclusion The detection of serum levels of Ang-2, VEGF, CA19-9 and CEA has clinical significance for the diagnosis of colon cancer. Combined detection can improve the diagnostic efficiency; the levels of Ang-2, VEGF, CA19-9 and CEA in serum before surgery colon cancer is associated with recurrence and metastasis, and combined testing can help to assess tumor metastasis.
