Expression and clinical significance of phosphoenolpyruvate carboxykinas and plaminogen activator inhibitor-1 in pleomorphic adenoma and adjacent tumor tissues of parotid gland
10.3969/j.issn.1006-5725.2019.03.014
- VernacularTitle:磷酸烯醇式丙酮酸羧激酶和纤溶酶原激活物抑制剂1在腮腺多形性腺瘤中的表达及其意义
- Author:
Gaofeng DING
1
;
Leiming GUO
;
Yufei LU
Author Information
1. 郑州大学附属肿瘤医院放疗科
- Keywords:
PCK;
PAI-1;
pleomorphic adenoma;
parotid gland
- From:
The Journal of Practical Medicine
2019;35(3):398-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of phosphoenolpyruvate carboxykinase (PCK) and plaminogen activator inhibitor-1 (PAI-1) in pleomorphic adenoma and adjacent tumor tissues of parotid gland. Methods Immunohistoehemistry was used to detect the expression of PCK and PAI-1 in10 cases of normal parotid glands, 38 cases of pleomorphic adenoma (0 cm) , adjacent tumor tissues (0.5, 1.0, 1.5, 2.0 cm from the pleomorphic adenoma). Results PCK expressed in all cases of normal parotid glands and adjacent tumor tissues, while PAI-1 expressed in 4 cases of normal parotid glands. Except 18 samples of 2.0 cm apart from pleomorphic adenoma, PAI-1 was expressed in the other adjacent tumor tissues. There was no obvious difference of PCK expression among normal, pleomorphic adenoma and adjacent tumor tissues of parotid glands (P> 0.05). The difference of PAI-1 expression was detected between pleomorphic adenoma (0 cm) and normal parotid glands and adjacent tumor tissues (2.0 cm from the tumor, P < 0.05). Conclusion During the development of pleomorphic adenoma, the expression level of PAI-1 is progressively increased while no change of PCK expression is found. It is rather remarkable that translocation of PAI-1 and PCK expression from cytoplasm and plasma membrane to nucleus occurs. The results mentioned above suggest that PCK and PAI-1 might play important roles in the progress of pleomorphic adenoma.
