The consistency of changes in macrocirculation and microcirculation in rats with severe hemorrhagic shock and septic shock
10.3969/j.issn.1006-5725.2019.03.011
- VernacularTitle:严重失血性休克与脓毒性休克大鼠大循环与微循环变化的一致性
- Author:
Qiaohua HU
1
;
Shengcai ZHENG
;
Qin LING
;
Liangliang WU
;
Zhengfei YANG
;
Xiangshao FANG
Author Information
1. 中山大学孙逸仙纪念医院急诊科
- Keywords:
shock;
hemorrhagic shock;
septic shock;
hemodynamics;
macrocirculation;
microcirculation
- From:
The Journal of Practical Medicine
2019;35(3):384-387
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes and coordination of macrocirculation and microcirculation in rats with severe hemorrhagic shock and septic shock. Methods A total of 20 male Sprague-Dawley rats (450～550 g) were randomly divided into two groups (n = 10) : hemorrhagic shock group (H-Shock) and septic shock group (S-Shock). 40％ of the systemic blood volume was withdrawn in 1 hour in H-Shock group.While in the S-Shock group, cereal ligation and puncture (CLP) was performed and then the abdomen was closed.Mean arterial pressure (MAP) and the end-tidal carbon dioxide (ETCO2) were recorded continuously. Cardiac ultrasonography and sublingual microcirculation were performed per hour till 12 hours or the rat die (End). A total of 12 hours were observed or the rat die. Arterial blood gas was measured at baseline (BL) , MAP ≤ 65 mmHg (Shock) and at the termination of observation respectively. Results The values reflect macrocirculation or microcirculation in the H-Shock group were all decreased than BL respectively at each time. In the S-Shock group, the values that reflect macrocirculation such as MAP, ETC02 and cardiac output (CO) showed no significant changes within 3 hours (P> 0.05) , while the values of microcirculation were decreased compared with BL respectively at each time (P < 0.05). With the progress of shock, the pH was decreased compared with BL in both groups, while the level of Lac were increased (P < 0.05). Conclusions The changes of macrocirculation and microcirculation in severe hemorrhagic shock are basically the same; while they are inconsistent in septic shock, the changes of microcirculation occurred earlier than that of macrocirculation.
