Changes and clinical significance of serum sLOX-1 and omentin-1 in patients with H-type hypertension complicated with acute ischemic stroke
10.3969/j.issn.1006-5725.2019.03.003
- VernacularTitle:H型高血压合并急性缺血性脑卒中患者血清可溶性凝集素样氧化型低密度脂蛋白受体-1、网膜素-1水平变化及意义
- Author:
Qihui CHENG
1
;
Dan YU
;
Guoshuai YANG
;
Yanhui ZHOU
;
Feng ZHOU
;
Rongdao SUN
;
Chunmiao LIU
;
Lü ZHOU
Author Information
1. 海口市人民医院(中南大学湘雅医学院附属海口医院)神经内科
- Keywords:
acute ischemic stroke;
H-type hypertension;
soluble lectin-like oxidized low density lipoprotein receptor-1;
omentin-1;
NIHSS score;
mRS score
- From:
The Journal of Practical Medicine
2019;35(3):346-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) and omentin-1 in patients with H-type hypertension complicated with acute ischemic stroke, and to analyze the correlation of sLOX-1 and omentin-1 levels with the severity and prognosis of the disease.Methods Totally 136 patients with H-type hypertension complicated with acute ischemic stroke from February2017 to May 2018 were selected as observation group, and 136 non-acute ischemic stroke patients with H-type hypertension in the same period as the control group. The patients of observation group were divided into mild, moderate and severe sub-groups according to NIHSS score, and they were also divided into good prognosis group and poor prognosis group based on modified RANKIN scale (mRS) score. The serum sLOX-1 and omentin-1 levels were detected, and the correlation of sLOX-1 and omentin-1 levels with severity and prognosis of disease was analyzed. Results The serum sLOX-1 level of the observation group was higher, but the serum omentin-1 level lower than that of control group (P < 0.05). With the severity of the disease, the serum sLOX-1 level increased, but the serum omentin-1 level decreased (P < 0.05). The serum sLOX-1 level of good prognosis group was significantly lower, whereas the serum omentin-1 level significantly higher than that of poor prognosis group (P < 0.05). sLOX-1 was positively correlated with NIHSS score and mRS score, while omentin-1 was negatively correlated with NIHSS score and mRS score (P < 0.05). Conclusions The levels of serum sLOX-1 and omentin-1 are closely related to the severity and prognosis of patients with H-type hypertension complicated with acute ischemic stroke, which could be used as markers for evaluating the severity and prognosis of the patients.
