Thecorrelationanalysisofmammographyandclinicalfeaturesassociatedwith therecurrenceofearlystageoftripleGnegativebreastcancer
10.3969/j.issn.1002-1671.2019.03.013
- VernacularTitle:钼靶X线及临床特征与早期三阴乳腺癌复发的相关性分析
- Author:
Ping TIAN
1
;
Huajun XU
;
Huimei ZHANG
;
Junjun SHEN
Author Information
1. 湖州市中心医院1放射科
- Keywords:
tripleGnegativebreastcancer;
recurrence;
mammography;
immunohistochemistry
- From:
Journal of Practical Radiology
2019;35(3):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toexplorethecorrelationanalysisofmammographyandclinicalcharacteristicsassociatedwiththerecurrence ofearlystageoftripleGnegativebreastcancer(TNBC).Methods Thedataofmammographyandclinicalcharacteristicsof231TNBC patientsfromJanuary2009to October2017 wereretrospectivelyanalyzed,andthenthedifferencesofmammographyandclinical characteristicswerecomparedbetweenthepatientswithrecurrence(n=64)andthosewithoutrecurrence(n=167).Results Compared withthepatientswithoutrecurrence,thepresenceoffamilyhistoryinpatientswithrecurrencewashigherthanthosewithoutrecurrence (12.5%vs3.6%,P<0.05).Thehistologicalgradesofthepatientswithrecurrenceweremainlyshowedasgrade2(6.3%)and3(93.7%), andthehistologicalgradeinpatientswithrecurrencewashigherthanthosewithoutrecurrence(P<0.05).Themammographicfindingsin TNBCshowedthatthepatientswithrecurrenceweremorelikelytohavedensebreasttissue(84.4%),axillarylymphnodesinvasion (53.1%)andlowercalcification(12.5%)(P<0.05).Multivariatelogisticregressionanalysisshowedthatthefamilyhistoryofbreast cancer(P=0.01,OR=2.54),histologicalgradeof2(P=0.01,OR=2.23)and3(P<0.001,OR=3.79),mammographicdensity breasttissue(P=0.02,OR=2.32),calcification(P=0.02,OR=0.45),andaxillarylymphnodesinvasion(P=0.03,OR=1.75)were statisticallysignificancewithTNBCrecurrence.Conclusion Thefamilyhistory,histologicalgrade,thepresenceofdensebreasttissue andaxillarylymphnodesinvasionsatmammographywereassociatedwiththeincreasedriskofrecurrenceinTNBC,whilethepresenceof calcificationwasrelatedtothelowerriskofrecurrenceinTNBC.