Congenital heart disease and neurodevelopment in children from the perspective of genetics
10.3760/cma.j.issn.2095-428X.2019.08.020
- VernacularTitle:从遗传学角度看儿童先天性心脏病与神经发育
- Author:
Qiuman LI
1
,
2
;
Shushui WANG
;
Yufen LI
;
Zhiwei ZHANG
Author Information
1. 汕头大学医学院 515041
2. 广东省人民医院(广东省医学科学院)
- Keywords:
Congenital heart disease;
Neurodevelopment;
Genetics;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2019;34(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Children with congenital heart disease (CHD) are at risk of neurodevelopmental disorder (NDD) which can be manifested as a diversity of clinical type.Up to 20％-30％ of CHD children have genetic abnormalities.As an independent risk factor for NDD,genetic abnormalities may predict a poorer neurodevelopmental outcome in these children.Because neurodevelopmental outcomes are closely related to the presence of underlying syndromes or genetic abnormalities,early diagnosis is the key to establish the prognosis of it,which is conducive to provide guidance for the children and their families in early time.In order to draw the attention of pediatric clinicians and CHD families and provide more comprehensive support for those children,this brief review is written for illustrate the relationship between CHD children and their neurodevelopmental outcome from the perspective of genetics.
