Relationship between serum neutrophil gelatinase-associated apolipoprotein and cardiovascular events in patients with chronic renal disease
10.3760/cma.j.issn.1674-6090.2019.02.014
- VernacularTitle:慢性肾脏病患者血清中性粒细胞明胶酶相关载脂蛋白与心血管事件相关性分析
- Author:
Shuwen GONG
1
;
Haiying XIE
;
Jichao GUAN
;
Juanping SHAN
;
Shuijuan SHEN
;
Jianling HE
;
Qinghua LI
;
Shimin WANG
;
Tujian GONG
;
Sumei ZHANG
Author Information
1. 绍兴市人民医院 浙江大学绍兴医院肾内科 312000
- Keywords:
Chronic renal disease;
Neutrophil gelatinase-associated apolipoprotein;
Cardiovascular events;
prognosis
- From:
Chinese Journal of Endocrine Surgery
2019;13(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between (serum neutrophil gelatinase-associated lipocalin,sNGAL) and cardiovascular events in patients with chronic kidney disease(CKD).Methods 300 patients with CKD were divided into two groups according to the level of sNGAL:high sNGAL group (n=158) and low sNGAL group (n=142).The incidence of cardiovascular events and cumulative survival rate were analyzed by ROC curve,and the correlation between sNGAL and cardiovascular risk factors,cardiovascular events in patients with chronic renal disease was analyzed.Influencing factors of cardiovascular events in CKD patients was analyzed.Results There were significant differences in the data about BMI,diabetes proportion,CKD staging,eGFR,hsCRP,24h proteinuria,HDL,iPTH,phosphate and blood calcium between the two groups (P＜0.05).The 3-year cumulative survival rate of high sNGAL group(77.2％) was significantly lower than that of low sNGAL group(96.5％),and the 3-year incidence of cardiovascular events (37.9％) was significantly higher than that of low sNGAL group (9.8％) (P＜ 0.05).AUC in diagnosing cardiovascular events in high sNGAL group (0.746) was significantly higher than that in eGFR(0.636),age (0.504),serum calcium (0.545),HDL(0.594) and LDL (0.508,all P＜0.05).There was a significant correlation between sNGAL and eGFR,HDL,BMI,hs-CRP,iPTH and phosphate (P＜ 0.05).Both univariate and multivariate fact ors COX showed that sNGAL was a risk factor of cardiovascular events in patients with CKD (P＜0.05),((HR=1.976 and 1.588,95％ CI=1.443-2.724 and 1.144-2.143,respectively,P=0.O00 and 0.000)).Conclusions The incidence of cardiovascular events in patients with CKD with high sNGAL is significantly increased.sNGAL is an independent factor of cardiovascular events in patients with chronic renal disease.
