Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, and appropriate cut off values forprediction of early-stage diabeticnephropathy
10.3760/cma.j.issn.1674-6090.2019.01.018
- VernacularTitle:比较中性粒细胞/淋巴细胞、血小板/淋巴细胞和平均血小板体积对早期糖尿病肾病的预测价值
- Author:
Ranran HUANG
1
;
Yingying XU
;
Shi CHEN
Author Information
1. 浙江中医药大学附属第三医院老年病科 310005
- Keywords:
Inflammation maker;
Diabetic nephropathy;
Type 2 diabetes
- From:
Chinese Journal of Endocrine Surgery
2019;13(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare predictive diagnostic value of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and mean platelet volume,for early-stage diabetic nephropathy (EDN).Methods 245 patients with T2DM were divided into patients with EDN(EDN group,n=120) and patients without DN (T2DM group,n=125).116 healthy people were also enrolled in our study.Their clinical and biochemical data were collected.Results NLR (2.14±0.73 vs 1.78±0.58 vs 1.46±0.48,P＜0.05),PLR (116.11±36.43 vs 100.65±27.83 vs 90.24±26.17,P＜0.05) and MPV (11.29± 1.16 vs 10.37 ± 1.01 vs 9.78 ± 1.28,P＜0.05) were significantly higher in EDN group and T2DM group than those of the control group.NLR,PLR and MPV were significantly higher in EDN group than those of T2DM group.Logistic regression analysis showed that after correction of diabetes duration,blood pressure,lipid,and so on,NLR(OR=3.77,95％ CI 2.12-6.08,P＜0.01),PLR(OR=1.81,95％ CI 1.02-2.89,P=0.04) and MPV (OR=2.08,95％ CI 1.22-5.04,P=0.01) were all positively correlated with EDN.According to the analysis of ROC curves,the value of NLR for predicting EDN was higher than PLR and MPV.The cut off value of NLR for predicting EDN was set at 1.82,with the sensitivity of 79.20％ and the specificity of 68.60％.Conclusion NLR has the greatest diagnostic value for EDN,patients whose NLR is over 1.82 need further test in order to diagnose and therapy DN earlier.
