Diagnostic values of 99Tcm-MIBI SPECT /CT imaging and planar imaging semi-quantitative analysis in primary hyperparathyroidism
10.3760/cma.j.issn.1674-6090.2019.01.005
- VernacularTitle:99Tcm-MIBI SPECT/CT显像及平面显像半定量分析对原发性甲状旁腺功能亢进症的诊断价值
- Author:
Jiali TANG
1
,
2
;
Dong DUAN
;
Hui ZHANG
Author Information
1. 重庆医科大学附属第一医院核医学科 400016
2. 自贡市第一人民医院核医学科 643000
- Keywords:
Hyperparathyroidism;
Primary;
Technetium (99mTc) sestamibi;
Single photon emission computed tomogmphy;
Computed tomography
- From:
Chinese Journal of Endocrine Surgery
2019;13(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of 99Tcm-MIBI SPECT/CT imaging and 99Tcm-MIBI planar imaging semi-quantitative analysis in primary hyperparathyroidism (PHPT).Methods A total of 89 patients were enrolled into this retrospective study.The diagnostic efficiencies of 99Tcm-MIBI SPECT/CT were compared with 9Tcm-MIBI planar scintigraphy and ultrasound,while the surgical pathology and the clinical follow-up results were considered as the standard.The region of interest extraction technique was used to measure and calculate the tumour to normal tissue ratios (T/NT) in the early and delayed phase of the planar scintigraphy,and the correlation between pathological type,PTH concentration and T/NT ratios was analyzed.Results The sensitivities and specificities of SPECT/CT,99Tcm-MIBI planar scintigraphy and ultrasound were 98.08％,88.46％,78.43％;82.93％,82.93％,58.82％ respectively.There were statistically significant correlations between the pathological type and PTH concentration,early phase T/NT and delayed phase T/NT,and the correlation coefficients r were 0.741,0.642 and 0.729,respectively.Conclusions 99Tcm-MIBI SPECT/CT imaging is an effective method for diagnosis of PHPT,with higher clinical application value than 99Tcm-MIBI planar scintigraphy and ultrasound.The semi-quantitative analysis of 99Tcm-MIBI planar scintigraphy provides a new method for the differential diagnosis of PHPT.
