Correlation between serum thyroid hormones with glucose and lipid metabolism in children with type 1 diabetes
10.3760/cma.j.issn.1674-6090.2018.06.007
- VernacularTitle:初发儿童1型糖尿病患者甲状腺激素水平与糖脂代谢的相关性研究
- Author:
Haiyan SU
1
;
Xiaoou SHAN
;
Kang LIN
;
Handan JIANG
;
Linwei SHI
Author Information
1. 325000,温州医科大学附属第二医院、育英儿童医院儿童内分泌遗传代谢科
- Keywords:
Serum thyroid hormones;
Glucose and lipid metabolism;
Type 1 diabetes
- From:
Chinese Journal of Endocrine Surgery
2018;12(6):469-472,477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of serum thyroid hormones with glucose and lipid metabolism in children with type 1 diabetes (T1DM) whose thyroid functions with normal.Methods 50 T1DM and 71 healthy children were enrolled in our study.Their blood glucose,lipid,HbA1c and thyroid functions were determined.Results Compared with the control group,patients with T1DM had higher low density lipoproteincholesterol (LDL-C),triglyceride(TG),fasting blood glucose (FBG) and HbA1c while with lower high density lipoprotein-cholesterol (HDL-C),thyroid Stimulating Hormone (TSH),and free triiodothyronine (FT3) (P＜0.05).In children with T1DM,TSH was positively correlated with LDL-C (r=0.175,P=0.034),total cholesterol (TC)(r=0.187,P=0.009) and TG(r=0.206,P=0.005) while negatively correlated with FBG(r=-0.187,P=O.018) and HbA1c (r=-0.264,P＜0.001).FT3 was negatively correlated with TG (r=-0.185,P=O.012),FBG (r=-0.193,P=O.O07) and HbA1c 0=-0215,P=0.002).But there were no correlations of FT4 with glucose or lipid metabolism.Conclusion TSH and FT3 are significantly correlated with glucose and lipid metabolism in children with T1DM.
